国家神经系统疾病临床医学研究中心数据管理与共享系统

Despite a significant body of literature on PD subtypes, there have been hardly any changes in clinical and research practice resulting from subtypes. Lack of advances in understanding aetiology and developing curative treatment have resulted in criticisms of subtyping methodology, which to date has been largely descriptive of subtypes rather than predictive of subtype or prognosis. With an increasing number of PD-specific datasets, the future of PD subtyping is finding consensus across clustering from multiple datasets to discover truly replicable subtypes and facilitate their widespread adoption into research and clinical practice.