Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Cumulative alcohol consumption and stroke risk in men
First author：Duan Yuxiang,Wang Anxin
Corresponding author：Wu Shouling,Yang Li
essential_information
- Person in charge：Duan Yuxiang,Wang Anxin
- Data Sources： Kailuan Study
- Number of papers：OTHERS20190798
- Published time：2019-05-22
2019-05-22
Published articles
Journal：Journal of neurology
Publication type: Original Communication
IF(IF): 4.849
PMID: 31119451 Link To Pubmed Full text Download
Background And Purpose
Method
This prospective study included 23,433 men from the Kailuan Study. Cumulative alcohol consumption was taken as the primary exposure by calculating self-reported alcohol consumption from three consecutive examinations (in 2006, 2008, and 2010). The first occurrence of stroke was confirmed by reviewing medical records from 2010 to 2016. We used Cox proportional hazards regression to analyze the data.
Conclusion
Cumulative alcohol consumption is an independent risk factor of total stroke and IS in men in a community-based cohort. Even light alcohol intake increases the risk of total stroke and IS.
Main results
During the 5.9±0.8years of follow-up, 678 total strokes were identified, including 595 ischemic stroke (IS), 90 intracerebral hemorrhage and 19 subarachnoid hemorrhage cases. The adjusted hazard ratios (95% confidence intervals) of total stroke for light, moderate and heavy cumulative alcohol consumption were 1.23 (1.01-1.51), 1.49 (1.13-1.97), and 1.50 (1.21-1.86), respectively, compared with those of nondrinkers. The results were similar for IS. Cumulative alcohol consumption was not associated with intracerebral hemorrhage risk (hazard ratio 1.46; 95% confidence interval, 0.74-2.08).