国家神经系统疾病临床医学研究中心数据管理与共享系统

发表杂志：Carcinogenesis

发表类型: Original Article

影响因子(IF): 4.944

PMID: 31157866 Pubmed原文链接 全文下载

Then, we derived a risk signature of 25 selected 1p19q genes that not only had prognosis value in total 1p/19q non-codel gliomas but also had prognosis value in stratified gliomas. The prognosis value of the risk signature was superior than known clinicopathological features in 1p/19q non-codel gliomas and was also highly associated with the following features: loss of CDKN2A/B copy number in mutant-IDH-astrocytoma; TERT promoter mutation, combined chromosome 7 gain / chromosome 10 loss, and EGFR amplification in wildtype-IDH-astrocytoma; Classical and Mesenchymal subtypes in glioblastoma. Furthermore, genes enriched in the biological processes of cell division, extracellular matrix, angiogenesis significantly correlated to the signature risk-score, and this is also supported by the immunohistochemistry and cell biology experiments. In conclusion, the expression profile of 1p19q genes is highly associated with the malignancy and prognosis of 1p/19q non-codel gliomas. A 25-1p19q-gene signature has powerfully predictive value for both malignant molecular pathological features and prognosis across distinct subgroups of 1p/19q non-codel gliomas.