国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder

第一作者：Liu Yaou,Dong Di

通讯作者：Liu Yaou ,Tian Jie

Multiple sclerosis . Neuromyelitis optica spectrum

基本信息

2019-02-15

已发表文章

发表杂志：European radiology

发表类型: Research Article

影响因子(IF): 5.315

PMID: 30770971 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We retrospectively collected 67 MS and 68 NMOSD with spinal cord lesions as a primary cohort and prospectively recruited 28MSand 26NMOSDpatients as a validation cohort.Radiomic features were extracted fromthe spinal cord lesions.A prediction model for differentiating MS and NMOSD was built by combining the radiomic features with several clinical and routineMRI measurements. The performance of the model was assessed with respect to its calibration plot and clinical discrim- ination in the primary and validation cohorts.

结论

Avalidated nomogram that incorporates the radiomic signature of spinal cord lesions, as well as cord lesion length, sex, and EDSS score, can usefully differentiate MS and NMOSD.

主要结果

Nine radiomics features extracted from an initial set of 485, predominantly reflecting lesion heterogeneity, combined with lesion length, patient sex, and EDSS, were selected to build the model for differentiating MS and NMOSD. The areas under the ROC curves (AUC) for differentiating the two diseases were 0.8808 and 0.7115, for the primary and validation cohort, respectively. This model demonstrated good calibration (C-index was 0.906 and 0.802 in primary and validation cohort).