Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Alpha-Synuclein in Peripheral Tissues in Parkinson's Disease
First author：Ma Ling-Yan
Corresponding author：Feng Tao
essential_information
- Person in charge：Ma Ling-Yan
- Data Sources： OTHERS
- Number of papers：OTHERS20190808
- Published time：2019-02-20
2019-02-20
Published articles
Journal：ACS chemical neuroscience
Publication type: Review
IF(IF): 4.418
PMID: 30714719 Link To Pubmed Full text Download
Background And Purpose
Method
Neuronal loss in the substantia nigra pars compacta (SNc) associated with Lewy bodies/neurites is the pathological hallmark feature of PD. The major component of Lewy pathology (LP) is misfolded alpha-synuclein (α-SYN). There is evidence that the distribution of LP is not only limited to the brain but extends to peripheral tissues, including gastrointestinal tract, salivary glands, olfactory mucosa, skin, retina, adrenal gland, and heart. Sensitivity and specificity of α-SYN detection in PD vary greatly among studies due to methodological heterogeneity, such as sampling sites and size, tissue preparation, staining techniques, and antibodies used. Of note, α-SYN has also been found in preclinical and prodromal PD.
Conclusion
Further in vivo studies focusing on favorable biopsy sites and standard techniques are needed to get better understanding of α-SYN deposits in preclinical, prodromal, and clinical PD.