Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The Morphological and Hemodynamic Characteristics of the Intraoperative Ruptured Aneurysm
First author：Liu Qingyuan
Corresponding author：Wang Shuo
essential_information
- Person in charge：Liu Qingyuan
- Data Sources： OTHERS
- Number of papers：OTHERS20190813
- Published time：2019-03-26
2019-03-26
Published articles
Journal：Front Neurosci
Publication type: Original Research
IF(IF): 3.648
PMID: 30971874 Link To Pubmed Full text Download
Background And Purpose
Method
In the present study, patients admitted for unruptured IA from January 2012 to April 2018 were retrospectively reviewed. A propensity score matching was performed to match patients. The morphological features and the hemodynamic features were extracted. Differences in the morphologic and hemodynamic parameters were compared. Risk factors associated with IOR were explored. Subsequently, the hemodynamic characteristics in different rupture stages and different regions in IOR aneurysm were compared.
Conclusion
AR, NWSSm, and OSI are considered three independent risk factors for intraoperative aneurysm rupture, which could serve as predictors. A selection of intervention methods for aneurysms with high AR, low NWSSm, and high OSI should carefully be considered.
Main results
96 cases of patients with aneurysms, were found by the matching process in each group. The statistically significant difference was found in the maximum length (L) (p = 0.041), maximum diameter of body (D) (p = 0.032), aspect ratio (AR) (p < 0.001), non-sphericity index (NSI) (p < 0.001), normalized wall shear stress maximum (NWSSm) (p < 0.001) and oscillatory shear index (OSI) (p < 0.001). A regression analysis demonstrated AR (OR = 7.03, p < 0.001), NWSSm (OR = 15.55, p = 0.014) and OSI (OR = 28.30, p < 0.001) as the independent risk factors for IOR. AR was much larger, and NWSSm and NWSSa were much lower for IAs that ruptured in early or pre-dissection stage than those for IAs that ruptured in dissection stage or clip application stage. NWSSa and NWSSm in rupture area were both lower than those in adjacent area.