Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Sirtuin 3 Mediates Tau Deacetylation
First author：Li Shiping,Yin Junxiang
Corresponding author：Shi Jiong
essential_information
- Person in charge：Li Shiping,Yin Junxiang
- Data Sources： OTHERS
- Number of papers：OTHERS20190814
- Published time：2019-03-08
2019-03-08
Published articles
Journal：Journal of Alzheimers Disease
Publication type: Research Article
IF(IF): 4.472
PMID: 30958373 Link To Pubmed Full text Download
Background And Purpose
Method
We studied the effects of Sirt3 on tau acetylation and its aggregations.
Conclusion
Sirt3 may play a role in tau acetylation and could be a potential target for novel therapy to alleviate tau accumulation.
Main results
We investigated the protein levels of Sirt3 and tangle tau in human postmortem brains slices from AD, mild cognitive impairment, and age- and education-matched cognitively normal subjects, and AD model mice. We also measured tau acetylation levels in hippocampal HT22 cells after Sirt3 knockdown or overexpression.