国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
基本信息
- 负责人：Li Shiping,Yin Junxiang
- 数据来源： OTHERS
- 论文编号：OTHERS20190814
- 发表时间：2019-03-08
2019-03-08
已发表文章
发表杂志：Journal of Alzheimers Disease
发表类型: Research Article
影响因子(IF): 4.472
PMID: 30958373 Pubmed原文链接 全文下载
主要研究背景及目的
方法
We studied the effects of Sirt3 on tau acetylation and its aggregations.
结论
Sirt3 may play a role in tau acetylation and could be a potential target for novel therapy to alleviate tau accumulation.
主要结果
We investigated the protein levels of Sirt3 and tangle tau in human postmortem brains slices from AD, mild cognitive impairment, and age- and education-matched cognitively normal subjects, and AD model mice. We also measured tau acetylation levels in hippocampal HT22 cells after Sirt3 knockdown or overexpression.