国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Clinical, Structural, and Neuropathological Features of Olfactory Dysfunction in Patients with Alzheimer's Disease
第一作者：Lian Teng-Hong
通讯作者：Zhang Wei
基本信息
- 负责人：Lian Teng-Hong
- 数据来源： OTHERS
- 论文编号：OTHERS20190815
- 发表时间：2019-06-04
2019-06-04
已发表文章
发表杂志：Journal of Alzheimer's disease
发表类型: Research Article
影响因子(IF): 3.517
PMID: 31177212 Pubmed原文链接 全文下载
主要研究背景及目的
方法
Olfactory function was evaluated using the Sniffin' Sticks test and a threshold discrimination identification (TDI) score. Based on the TDI score, we divided patients according to the presence or absence of OD (AD-OD and AD-NOD, respectively). Cognitive and neuropsychiatric symptoms were evaluated by a series of rating scales. The volumes and cortical thickness of the thalamus, hippocampus, and amygdala were measured using structural magnetic resonance imaging. Neuropathological protein levels in cerebrospinal fluid were measured.
结论
Overall, in AD patients, the impairments in olfactory discrimination and identification seems to be more correlated with cognitive levels. OD in AD may be an indicator of pathological cognitive decline and structural changes.
主要结果
The frequency of OD was 50%. TDI scores were lower in the AD-OD group than in the AD-NOD group (p < 0.001). Compared with the AD-NOD group, the AD-OD group showed greater cognitive function impairments (p < 0.001), and daily living activities were more severely compromised (p = 0.019). The AD-OD group had lower hippocampal and amygdala volumes (p = 0.025, p = 0.030, respectively) and a more pronounced reduction in cortical thickness (p = 0.010). The total tau level was lower in the AD-OD group than the AD-NOD group (p = 0.040). Lower Mini-Mental State Examination scores and thinner AD-signature cortices were associated with lower TDI scores (OR = 0.826, p < 0.001; OR = 1.433, p = 0.008).