Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Clinical, Structural, and Neuropathological Features of Olfactory Dysfunction in Patients with Alzheimer's Disease
First author：Lian Teng-Hong
Corresponding author：Zhang Wei
essential_information
- Person in charge：Lian Teng-Hong
- Data Sources： OTHERS
- Number of papers：OTHERS20190815
- Published time：2019-06-04
2019-06-04
Published articles
Journal：Journal of Alzheimer's disease
Publication type: Research Article
IF(IF): 3.517
PMID: 31177212 Link To Pubmed Full text Download
Background And Purpose
Method
Olfactory function was evaluated using the Sniffin' Sticks test and a threshold discrimination identification (TDI) score. Based on the TDI score, we divided patients according to the presence or absence of OD (AD-OD and AD-NOD, respectively). Cognitive and neuropsychiatric symptoms were evaluated by a series of rating scales. The volumes and cortical thickness of the thalamus, hippocampus, and amygdala were measured using structural magnetic resonance imaging. Neuropathological protein levels in cerebrospinal fluid were measured.
Conclusion
Overall, in AD patients, the impairments in olfactory discrimination and identification seems to be more correlated with cognitive levels. OD in AD may be an indicator of pathological cognitive decline and structural changes.
Main results
The frequency of OD was 50%. TDI scores were lower in the AD-OD group than in the AD-NOD group (p < 0.001). Compared with the AD-NOD group, the AD-OD group showed greater cognitive function impairments (p < 0.001), and daily living activities were more severely compromised (p = 0.019). The AD-OD group had lower hippocampal and amygdala volumes (p = 0.025, p = 0.030, respectively) and a more pronounced reduction in cortical thickness (p = 0.010). The total tau level was lower in the AD-OD group than the AD-NOD group (p = 0.040). Lower Mini-Mental State Examination scores and thinner AD-signature cortices were associated with lower TDI scores (OR = 0.826, p < 0.001; OR = 1.433, p = 0.008).