Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of Body Mass Index and Risk of Stroke After Acute Minor Stroke or TIA: a Post Hoc Analysis of a Randomized Controlled Trial
First author：Chen Weiqi
Corresponding author：Lin Yi,Wang Yongjun
essential_information
- Person in charge：Chen Weiqi
- Data Sources： CHANCE
- Number of papers：OTHERS20190818
- Published time：2019-05-24
2019-05-24
Published articles
Journal：Neurotox Res
Publication type: Original Article
IF(IF): 3.911
PMID: 31127478 Link To Pubmed Full text Download
Background And Purpose
Method
A total of 5163 patients with available BMI data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial were included. Patients were classified into three groups according to their BMI values: normal weight (< 23.9 kg/m2), overweight (24-27.9 kg/m2), and obese (≥ 28.0 kg/m2). The efficacy outcomes included a new stroke (ischemic or hemorrhagic), poor functional outcome defined as modified Rankin scale ≥ 2 points and death from any cause within 90 days. The interaction effects were determined using multivariable Cox or logistic regression models.
Conclusion
For patients with a minor ischemic stroke or TIA, being overweight was associated with an increased risk of recurrent stroke compared to being of normal weight in our study.
Main results
After 90 days of follow up, there were 513 new strokes. Overweight (BMI 24-27.9 kg/m2) patients had a higher risk of recurrent strokes than those with normal weight (10.8% vs 8.8%; HR = 1.24, 95% CI 1.02-1.50) after adjusting for the baseline covariates, but no significant association was observed for those who were obese (P = 0.37). No significant association was found between being overweight or obese and poor functional outcome or death.