国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Effect of cornel iridoid glycoside on microglia activation through suppression of the JAK/STAT signalling pathway

第一作者：Qu Zhao,Zheng Na,Wei Yuzhen

通讯作者：Geng Xingchao,Wang Qi,Yin Linlin

Cornel iridoid glycoside; JAK/STAT pathway; Microg

基本信息

2019-05-15

已发表文章

发表杂志：Journal of Neuroimmunology

发表类型: Research Article

影响因子(IF): 3.478

PMID: 30852182 Pubmed原文链接 全文下载

主要研究背景及目的

方法

We induced a mouse model of multiple sclerosis (MS), namely, the experimental autoimmune encephalomyelitis (EAE) model by immunization subcutaneously with the MOG35-55 peptide, which causes neuroinflammation and microglia activation.

结论

Based on our findings, CIG might be a promising candidate for the prevention of neurological disorders such as multiple sclerosis (MS).

主要结果

Our data demonstrated that CIG delayed the onset of the EAE, ameliorated the severity of the symptoms and inhibited the activation of microglia in different brain regions. In addition, we also found that CIG has therapeutic potential by modulating microglia polarization by reducing the expression and release of proinflammatory cytokines, chemokines and inhibiting phosphorylation in the JAK/STAT cell signalling pathway.