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Effect of cornel iridoid glycoside on microglia activation through suppression of the JAK/STAT signalling pathway
First author：Qu Zhao,Zheng Na,Wei Yuzhen
Corresponding author：Geng Xingchao,Wang Qi,Yin Linlin
essential_information
- Person in charge：Qu Zhao,Zheng Na,Wei Yuzhen
- Data Sources： OTHERS
- Number of papers：OTHERS20190825
- Published time：2019-05-15
2019-05-15
Published articles
Journal：Journal of Neuroimmunology
Publication type: Research Article
IF(IF): 3.478
PMID: 30852182 Link To Pubmed Full text Download
Background And Purpose
Method
We induced a mouse model of multiple sclerosis (MS), namely, the experimental autoimmune encephalomyelitis (EAE) model by immunization subcutaneously with the MOG35-55 peptide, which causes neuroinflammation and microglia activation.
Conclusion
Based on our findings, CIG might be a promising candidate for the prevention of neurological disorders such as multiple sclerosis (MS).
Main results
Our data demonstrated that CIG delayed the onset of the EAE, ameliorated the severity of the symptoms and inhibited the activation of microglia in different brain regions. In addition, we also found that CIG has therapeutic potential by modulating microglia polarization by reducing the expression and release of proinflammatory cytokines, chemokines and inhibiting phosphorylation in the JAK/STAT cell signalling pathway.