国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
2019-01-21
已发表文章
发表杂志：Journal of vascular nursing
发表类型: Research Article
影响因子(IF): 2.51
PMID: 30954193 Pubmed原文链接 全文下载
主要研究背景及目的
方法
This study is based on a prospective cohort (in-hospital medical complication after acute stroke [iMCAS] registry) enrolling patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). In-hospital DVT was diagnosed by clinical manifestations and verified by compression Doppler ultrasound. A logistic regression analysis was performed to assess the association between stroke subtypes and occurrence of DVT.
结论
In conclusion, patients with hemorrhagic stroke (ICH and SAH) have significantly higher risk of in-hospital DVT than patients with AIS. Further studies on pathophysiologic mechanisms are warranted.
主要结果
A total number of 1,771 patients were enrolled in the iMCAS. The mean age was 57.1 ± 12.9 years, and 27.5% were female patients. The median length of stay was 14 days (interquartile range [IQR], 11-16). The median National Institutes of Health Stroke Scale score on admission for patients with AIS, ICH, and SAH was 4 (IQR: 2-8), 4 (IQR:1-10), and 0 (IQR:0-0), respectively. In-hospital DVT after AIS, ICH, and SAH was 1.9%, 5.7%, and 7.9%, respectively. The median time from stroke onset to DVT formation after AIS, ICH, and SAH was 10.5 days (IQR: 3.8-14.5), 7.5 days (IQR:4.0-9.5), and 7.0 days (IQR:5.0-12.5), respectively. After adjusting for potential confounders, patients with ICH (odds ratio = 7.350; 95% confidence interval = 2.411-22.13; P < .001) and SAH (odds ratio = 11.92; 95% confidence interval = 5.192-27.38; P < .001) had significantly higher risk of in-hospital DVT than those patients with AIS.