Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Stenting for symptomatic intracranial arterial stenosis in China: 1-year outcome of a multicentre registry study
First author：Ma Ning
Corresponding author：Miao Zhongrong
essential_information
2018-09-01
Published articles
Journal：Stroke Vasc Neurol
Publication type: Original Article
IF(IF): 4.081
PMID: 30294474 Link To Pubmed Full text Download
Background And Purpose
Method
Patients with symptomatic ICAS caused by 70%–99%stenosis located at the intracranial internal carotid, middle cerebral, intracranial vertebral or basilar arteries combined with poor collaterals were enrolled. Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators. The primary outcome was the rate of 30-day stroke, transient ischaemic attack and death, and 12-month ischaemic stroke within the same vascular territory, haemorrhagic stroke and vascular death after stenting.
Conclusion
The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals. Further randomised trial of comparing individually tailored stenting with best medical therapy is needed.
Main results
From September 2013 to January 2015, 300 patients (ages 58.3±9.78 years) were recruited. Among them, 159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent. During the 1-year follow-up, 25 patients had a primary end point event. The probability of primary outcome at 1year was 8.1% (95% CI 5.3% to 11.7%). In 76 patients with digital subtraction angiography follow-up, 27.6% (21/76) had re-stenosis ≥50%and 18.4% (14/76) had re-stenosis ≥70%. No baseline characteristic was associated with the primary outcome.