Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：Cerebrovascular diseases

Publication type: Original Contributions

IF(IF): 3.104

PMID: 34923942 Link To Pubmed Full text Download

Background: YKL-40, also called as human Chitinase 3-like 1 immunoassay. is one of an inflammatory marker of ischemic cardiovascular and cerebrovascular disease. Increased blood levels double the risk of ischemic stroke [HR (95% CI): 1.99 (1.42-2.67)]. The mechanism may be related to thin plaque cap and plaque vulnerability. A study involved 296 people with carotid plaques found vulnerable carotid plaques in the YKL-40 high-level group was 2.653 times higher than that in the low-level group (95% CI 1.002- 7.023) after adjusting for multiple risk factors. However, the relationship between YKL-40 and ischemic stroke remains to be determined.

Multivariate analysis explored the relationship between blood YKL-40 levels and ischemic stroke recurrence and functional prognosis: Logit model with multi-class response variables was used to adjust age, gender, smoking, blood pressure, blood glucose, blood lipids, CRP, intraplaque bleeding, etc. For possible confounding factors, multiple correction models are used. Model 1 uses crude rate; Model 2 uses adjusted age and gender. Model 3 adds proofreading smoking based on Model 2. Model 4 adds proofreading blood pressure, blood glucose, lipids, and CRP based on Model 3. Model 5 is based on model 3 with proofreading of NIHSS. Model 6 is based on model 3 with proofreading of C-reactive protein. To investigate the relationship between the levels of various inflammatory factors and the recurrence and functional prognosis of ischemic stroke.