国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Homocysteine and Clinical Outcomes in Intracerebral Hemorrhage Patients: Results from the China Stroke Center Alliance

第一作者：Dandan Wang

通讯作者：Yongjun Wang,Xingquan Zhao

intracerebral hemorrhage homocysteine stroke severity outcome

基本信息

  • 负责人：Dandan Wang
  • 数据来源： CSCA
  • 论文编号：CSCA20200017
  • 发表时间：2022-12-07

2022-12-07

已发表文章

发表杂志：Neuropsychiatric Disease and Treatment

发表类型: Original Contributions

影响因子(IF): 2.989

PMID: 36514491 Pubmed原文链接 全文下载

主要研究背景及目的

Homocysteine is an intermediate sulfhydryl-containing amino acid. According to previous studies, high level of Hcy could induce a neuro-inflammatory process due to its abilities to react with cytokines in the brain, leading to increased permeability of blood-brain barrier and impaired integrity of cerebral vessels. There is convincing evidence that elevated plasma Hcy level is associated with higher mortality rates from ischemic stroke, cardiovascular diseases and peripheral artery disease. However, it is still unclear whether the Hcy level is associated with the ICH and its severity. So we aimed to find the relationship between Hcy levels and ICH severity and related risk factors in a Chinese population.

方法

It is a cross-sectional study, and we aim to use chi-square test and logistic regression to test the relationship between the elevated homocysteine Level and the severity of ICH.

结论

An elevated Hcy level exhibited significant association with severe ICH on admission and a poor functional outcome at discharge. The relationship between HHcy and ICH severity on admission was more robust in female patients and patients without hypertension. Hcy might be a valuable biomarker for ICH patients to predict severity at onset and functional outcome at discharge.

主要结果