国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

High-sensitive C-reactive Protein Predicts Recurrent Stroke and Poor Functional Outcome: Subgroup Analysis of the CHANCE Tria

第一作者：黎洁洁

通讯作者：王拥军

hsCRP

基本信息

  • 负责人：黎洁洁
  • 数据来源： CHANCE
  • 论文编号：CHANCE20150147
  • 发表时间：2016-08-04

2016-08-04

已发表文章

发表杂志：stroke

发表类型: Original Contributions

影响因子(IF): 7.914

PMID: 27328699 Pubmed原文链接 全文下载

主要研究背景及目的

Minor stroke and transient ischemic attack (TIA) are common disorders with high rate of subsequent disabling stroke. To identify biomarker of stroke recurrence and functional disability may be helpful for clinicians plan and adjusting therapeutic strategy. We aim to investigate the role of high-sensitive C-reactive protein (hsCRP) in predicting recurrent stroke and poor functional outcome in the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial.

方法

The associations of hsCRP with recurrent stroke and mRS were analyzed by using Cox proportional-hazards and logistic regression models respectively.

结论

Elevated hsCRP (>3.0 mg/L) was observed in 32% of the study population. Patients with hsCRP >3 mg/L had an increased risk of recurrent stroke (adjusted hazard ratio, 1.46; 95% confidence interval, 1.08–1.98; P=0.039), ischemic stroke and combined vascular events, and poor functional outcome (adjusted odds ratio, 1.68; 95% confidence interval, 1.22–2.32; P=0.002) compared with those with hsCRP <1 mg/L within 90-day follow-up period. High hsCRP levels also independently predicted recurrent stroke during 1-year follow-up. There was no interaction of hsCRP levels with randomized antiplatelet therapy.

主要结果