Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The role of hypertension and diabetes mellitus on the etiology of middle cerebral artery disease
First author：Changqing Zhang
Corresponding author：Yongjun Wang
essential_information
- Person in charge：Changqing Zhang
- Data Sources： CICAS
- Number of papers：CICAS20200053
- Published time：2022-03-20
2022-03-20
Published articles
Journal：Brain and behavior
Publication type: Original Contributions
IF(IF): 3.405
PMID: 35307987 Link To Pubmed Full text Download
Background And Purpose
我国颅内大动脉粥样硬化所致缺血性脑血管病的比例远高于西方白人。大脑中动脉(middle cerebral artery, MCA)是国人颅内动脉狭窄最常见的部位，因此MCA分布区脑梗死也是颅内动脉狭窄所致脑梗死最常见的类型。目前关于国人大样本量MCA分布区脑梗死患者的临床和影像学特征及复发危险因素的研究较少，而且多数关于缺血性卒中复发危险因素的研究未将新发脑梗死灶的影像学分布特征和责任脑动脉狭窄程度考虑在内。因此，本研究的目的是分析MCA分布区非心源性缺血性卒中患者的临床和影像学特征及复发的危险因素。
Method
We consecutively enrolled 967 patients with noncardiogenic IS in unilateral MCA territory. Vascular risk factors and the clinical-radiologic features of IS were analyzed. The etiology of IS were classified as SAO or LAA according to the Stop Stroke Study Trial of Org 10172 in Acute Stroke Treatment classification criteria. Multivariable logistic regression was used to identify the differences in the predictors between SAO and LAA etiology of MCA disease.
Conclusion
Hypertension and diabetes mellitus are related with the different etiology of MCA disease.
Main results
Multivariable logistic regression identified male and hypertension as the predictors of the SAO etiology of MCA disease, however diabetes mellitus, repeated transient ischemic attack before the stroke, gaze palsy, aphasia, headache at admission, and disability at discharge as the predictors of the LAA etiology of MCA disease.