Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Impact of Infection on the Risk of Recurrent Stroke among Patients with Acute Ischemic Stroke.
First author：Jie Xu,Gulbahram Yalkun,
Corresponding author：Yongjun Wang,Zixiao Li
essential_information
- Person in charge：Jie Xu,Gulbahram Yalkun,
- Data Sources： CNSR-Ⅲ CSCA
- Number of papers：CSCA20200126
- Published time：2020-06-26
2020-06-26
Published articles
Journal：Stroke
Publication type: Original Contributions
IF(IF): 7.914
PMID: 32586226 Link To Pubmed Full text Download
Background And Purpose
Infection occurs commonly in patients with acute ischemic stroke. We aimed to investigate the association of infection with short- and long-term risk of recurrent stroke in patients with ischemic stroke.
Method
Data was derived from ischemic stroke patients in 2 stroke registries: The Chinese Stroke Center Alliance programme (CSCA) recorded medical data during hospitalization, and the Third China National Stroke Registry (CNSR-III) recorded the medical data during hospitalization and finished 1-year follow-up. Associations of infection (pneumonia or urinary tract infection) during hospitalization with recurrent stroke in short (during hospitalization) and long term (since 30 days to 1 year after stroke onset) were analyzed. Short-term outcomes were analyzed with Logistic models, and long-term outcomes with Cox models.
Conclusion
Infection was an independent risk factor for high risk of early stroke recurrence during hospitalization, but we have not found its sustained effect on long-term recurrent risk in patients with acute ischemic stroke.
Main results
In the CSCA (n=789,596), the incidence of infection during hospitalization reached 9.6%. Patients with infection had a higher risk of stroke recurrence during hospitalization compared with patients without infection (10.4% vs 5.2%; adjusted Odds Ratio [OR], 1.70; 95% Confidence Interval [95%CI], 1.65-1.75; P<0.0001). In the CNSR-III (n=13,549), the incidence of infection during hospitalization was 6.5%. Infection during hospitalization was significantly associated with short-term risk of recurrent stroke (7.4% vs 3.9%; adjusted OR, 1.40; 95%CI, 1.05-1.86; P=0.02), but not with long-term risk of recurrent stroke (7.2% vs 5.2%; adjusted Hazard Ratio, 1.16; 95%CI, 0.88-1.52; P=0.30).