国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Impact of Infection on the Risk of Recurrent Stroke among Patients with Acute Ischemic Stroke.

第一作者：Jie Xu,Gulbahram Yalkun,

通讯作者：Yongjun Wang,Zixiao Li

infection ◼ pneumonia ◼ risk factors ◼ stroke ◼ ur

基本信息

2020-06-26

已发表文章

发表杂志：Stroke

发表类型: Original Contributions

影响因子(IF): 7.914

PMID: 32586226 Pubmed原文链接 全文下载

主要研究背景及目的

Infection occurs commonly in patients with acute ischemic stroke. We aimed to investigate the association of infection with short- and long-term risk of recurrent stroke in patients with ischemic stroke.

方法

Data was derived from ischemic stroke patients in 2 stroke registries: The Chinese Stroke Center Alliance programme (CSCA) recorded medical data during hospitalization, and the Third China National Stroke Registry (CNSR-III) recorded the medical data during hospitalization and finished 1-year follow-up. Associations of infection (pneumonia or urinary tract infection) during hospitalization with recurrent stroke in short (during hospitalization) and long term (since 30 days to 1 year after stroke onset) were analyzed. Short-term outcomes were analyzed with Logistic models, and long-term outcomes with Cox models.

结论

Infection was an independent risk factor for high risk of early stroke recurrence during hospitalization, but we have not found its sustained effect on long-term recurrent risk in patients with acute ischemic stroke.

主要结果

In the CSCA (n=789,596), the incidence of infection during hospitalization reached 9.6%. Patients with infection had a higher risk of stroke recurrence during hospitalization compared with patients without infection (10.4% vs 5.2%; adjusted Odds Ratio [OR], 1.70; 95% Confidence Interval [95%CI], 1.65-1.75; P<0.0001). In the CNSR-III (n=13,549), the incidence of infection during hospitalization was 6.5%. Infection during hospitalization was significantly associated with short-term risk of recurrent stroke (7.4% vs 3.9%; adjusted OR, 1.40; 95%CI, 1.05-1.86; P=0.02), but not with long-term risk of recurrent stroke (7.2% vs 5.2%; adjusted Hazard Ratio, 1.16; 95%CI, 0.88-1.52; P=0.30).