Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
essential_information
2021-09-08
Published articles
Journal：Frontiers in Neurology
Publication type: Article
IF(IF): 4.003
PMID: 34566851 Link To Pubmed Full text Download
Background And Purpose
Atherosclerosis is a systemic disease. The occurrence of two or more vascular bed damage throughout the body is called polyvascular disease. Studies have shown that polyvascular disease had a great value in predicting the risk of cardiovascular and cerebrovascular events. However, the pathogenesis of TOAST type small artery occlusion stroke is mainly hyaline degeneration of the vessel wall, rather than atherosclerosis. The correlation between polyvascular disease and the risk of stroke recurrence and cardiovascular events in patients with csvd is unclear.
Method
In this study, patients with small vascular disease will be included. we will investigate the proportion of different vascular bed damage (CHD, PAD, CHD&PAD) in patients with csvd, and the risk of stroke recurrence and MACE.
Conclusion
Polyvascular disease is not associated with recurrence of stroke and MACEs in patients with recent lacunar stroke at 1 year.
Main results
Among 3 165 patients with recent lacunar stroke, CHD was present in 375 (11.8%) and peripheral arterial disease in 168 (5.3%). The hazard ratio (HR) for stroke recurrence was 0.98 (95% confidence interval [CI], 0.65–1.46; p = 0.91) for patients with CHD and lacunar stroke, 1.07 (95% CI, 0.61–1.87; p = 0.82) for patients with PAD and lacunar stroke, and 0.95 (95% CI, 0.66–1.35; p = 0.75) for patients with CHD/PAD and lacunar stroke compared with patients with isolated lacunar stroke. The HR for MACEs was 1.01 (95% CI, 0.69–1.49; p = 0.94) for patients with CHD and lacunar stroke, 1.11 (95% CI, 0.65–1.90; p = 0.71) for patients with PAD and lacunar stroke, and 0.99 (95% CI, 0.70–1.40; p = 0.95) for patients with CHD/PAD and lacunar stroke.