国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
2021-09-08
已发表文章
主要研究背景及目的
Atherosclerosis is a systemic disease. The occurrence of two or more vascular bed damage throughout the body is called polyvascular disease. Studies have shown that polyvascular disease had a great value in predicting the risk of cardiovascular and cerebrovascular events. However, the pathogenesis of TOAST type small artery occlusion stroke is mainly hyaline degeneration of the vessel wall, rather than atherosclerosis. The correlation between polyvascular disease and the risk of stroke recurrence and cardiovascular events in patients with csvd is unclear.
方法
In this study, patients with small vascular disease will be included. we will investigate the proportion of different vascular bed damage (CHD, PAD, CHD&PAD) in patients with csvd, and the risk of stroke recurrence and MACE.
结论
Polyvascular disease is not associated with recurrence of stroke and MACEs in patients with recent lacunar stroke at 1 year.
主要结果
Among 3 165 patients with recent lacunar stroke, CHD was present in 375 (11.8%) and peripheral arterial disease in 168 (5.3%). The hazard ratio (HR) for stroke recurrence was 0.98 (95% confidence interval [CI], 0.65–1.46; p = 0.91) for patients with CHD and lacunar stroke, 1.07 (95% CI, 0.61–1.87; p = 0.82) for patients with PAD and lacunar stroke, and 0.95 (95% CI, 0.66–1.35; p = 0.75) for patients with CHD/PAD and lacunar stroke compared with patients with isolated lacunar stroke. The HR for MACEs was 1.01 (95% CI, 0.69–1.49; p = 0.94) for patients with CHD and lacunar stroke, 1.11 (95% CI, 0.65–1.90; p = 0.71) for patients with PAD and lacunar stroke, and 0.99 (95% CI, 0.70–1.40; p = 0.95) for patients with CHD/PAD and lacunar stroke.