Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：BMC Neurology

Publication type: Research Article

IF(IF): 2.903

PMID: 35260102 Link To Pubmed Full text Download

Insulin resistance, measured by homeostasis model assessment–insulin resistance (HOMA-IR) index, was associated with an increased risk of stroke recurrence, death, and poor outcome in nondiabetic patients with acute ischemic stroke.[1] Previous studies showed triglyceride-glucose index (TyG index) could be useful as surrogate to identify insulin resistance in apparently healthy subjects.[2, 3] Some studies showed that TyG index was more independently associated with the presence of coronary artery atherosclerosis[4], carotid atherosclerosis[5] and the development of diabetes[6] than HOMA-IR. However, few studies have compared the effects of HOMA-IR and TyG index on predicting prognosis of nondiabetic patients with acute ischemic stroke. We aim to compare the effects of HOMA-IR and TyG index on predicting stroke recurrence and death in nondiabetic patients with ischemic stroke.

Nondiabetic acute ischemic stroke patients from the ACROSS-China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry were included. TyG index was performed and classified into four groups by quartiles. The outcomes were stroke recurrence and death within 1 year. The association between TyG index and the risk of stroke recurrence and death were analyzed by Cox regression models. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the prediction of TyG index and HOMA-IR for stroke recurrence and death. Delong test was used for comparing the differences between area under the curve (AUC) of TyG index and HOMA-IR.