Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：Atherosclerosis Plus

Publication type: Original Contributions

IF(IF): 1.585

PMID: https://doi.org/10.1016/j.athplu.2022.03.001 Link To Pubmed Full text Download

Ketone bodies (acetoacetate, acetone, and b-hydroxybutyrate [bOHB]) are metabolites that are well known as alternative energy sources. The ketone bodies become important under certain conditions as they can supplement energy to cells when glucose oxidation dramatically decreases. They accumulate in the plasma under conditions of fasting and uncontrolled diabetes. Though ketone bodies serve as substrates for energy, several deleterious effects of the accumulation of these moieties have been reported. Derangements of ketone body metabolism occur in numerous disease states, including types 1 and 2 diabetes and heart failure, and ketone body metabolism changes over the course of normal aging. Ketoacidosis occurs after the accumulation of ketone bodies, which can be detected by urine test as early sign. However, there is limited research on urine ketone bodies in the acute phase of ischemic stroke.

This study enrolled 14 015 patients with AIS or TIA who screened for urine ketone bodies from the Third China National Stroke Registry. Status of urine ketone bodies were classified into negative, suspicious positive and positive. The outcomes were all-cause death and poor functional outcomes (modified Rankin Scale [mRS] 2e6/3-6) at 3 months and 1 year. Multivariable Cox proportional hazards regressions and logistic regressions were adopted to explore the associations.