Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
An Analysis of the Potential Relationship of Triglyceride Glucose and Body Mass Index With Stroke Prognosis
First author：Zongyi Hou
Corresponding author：Yongjun Wang
essential_information
- Person in charge：Zongyi Hou
- Data Sources： Golden Bridge
- Number of papers：GOLDEN BRIDGE20200158
- Published time：2021-04-22
2021-04-22
Published articles
Journal：Frontiers in Neurology
Publication type: Original Contributions
IF(IF): 4.003
PMID: 33967936 Link To Pubmed Full text Download
Background And Purpose
肥胖通常与中风风险增加有关；然而，许多研究都表明中风后超重和肥胖患者的预后较好。这被称为“肥胖卒中悖论”。然而有研究表明，这种悖论在胰岛素抵抗患者中存在，而在胰岛素敏感患者中不存在。甘油三酯葡萄糖指数(TYG)与缺血性卒中患者复发、全因死亡率和神经功能恶化的风险增加相关。TYG指数被提出可以作为胰岛素抵抗(IR)的简单替代标志物。我们试图联合分析甘油三酯葡萄糖指数和体重指数与卒中预后的关系，观察TYG指数是否可以改变BMI与卒中预后的关系
Method
We identified 12,964 ischemic stroke patients without a history of diabetes mellitus from the China National Stroke Registry and classified patients as either low/normal weight, defined as a BMI <25 kg/m2, or overweight/obese, defined as a BMI ≥ 25 kg/m2. We calculated TYG index and based on which the patients were divided into four groups. A Cox or logistic regression model was used to evaluate the association between BMI and TYG index and its influence on stroke outcomes, including stroke recurrence all-cause mortality and poor outcome (modified Rankin Scale score of 3–6) at 12 months.
Conclusion
Overweight/obese patients with ischemic stroke have better survival than patients with low/normal weight. The association of BMI and stroke outcome is not changed by TYG index.
Main results
Among the patients, 63.3% were male, and 36.7% were female, and the mean age of the patient cohort was 64.8 years old. The median TYG index was 8.62 (interquartile range, 8.25–9.05). After adjusting for multiple potential covariates, the all-cause mortality of overweight/obese patients was significantly lower than that of the low/normal weight patients (6.17 vs. 9.32%; adjusted hazard ratio, 0.847; 95% CI 0.732–0.981). The difference in mortality in overweight/obese and low/normal weight patients with ischemic stroke was not associated with TYG index, and no association between BMI and TYG index was found.