国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
No Association Between Postmenopausal Time and the Prevalence of Newly Discovered Asymptomatic Intracranial Atherosclerotic Stenosis: The APAC Study
第一作者：changfeng fan
通讯作者：xingquan zhao
基本信息
- 负责人：changfeng fan
- 数据来源： APAC
- 论文编号：APAC20200161
- 发表时间：2020-04-24
2020-04-24
已发表文章
发表杂志：Journal of Clinical Neuroscience
发表类型: Original Articles
影响因子(IF): 1.961
PMID: 32340844 Pubmed原文链接 全文下载
主要研究背景及目的
Introduction Asymptomatic intracranial atherosclerotic stenosis (AICAS) is a common cause of stroke. Elderly women were more likely than men to develop AICAS, although it indicated that a lifelong exposure to estrogen could lower the risks of cardiovascular disease (CVDs). Objective The present study aims to ascertain whether postmenopausal time is a risk factor of AICAS. Fostering a correct perception of menopause is of great significance for the overall well-being of the elderly women.
方法
Methods All participants received a questionnaire, physical examination, laboratory testing and transcranial Doppler. The menopausal population (n=701) was divided into three groups by tertiles of postmenopausal time. Two-tailed testing and trend test were used to reveal the relationship between postmenopausal time and newly discovered AICAS. Other potential risk factors were also analyzed to ascertain whether there was a relation between postmenopausal time and the newly discovered ICAS.
结论
Postmenopausal time is not an independent risk factor of AICAS. No relationship was detected between postmenopausal time and newly discovered AICAS, while vigorous control of body weight, blood pressure/glucose/lipids and smoke cessation are vital for preventing the occurrence of AICAS.
主要结果
Both mean age and mean postmenopausal time were gradually increased from G0 to G2. The same trend occurred in hypertension, diabetes mellitus, total cholesterol, triglyceride, C-reactive protein and serum homocysteine. Adjusting for various confounding factors, postmenopausal time was not a risk factor for newly discovered AICAS. Multifactor analysis and stratifying analysis showed no correlation between newly discovered AICAS and postmenopausal time.