Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
No Association Between Postmenopausal Time and the Prevalence of Newly Discovered Asymptomatic Intracranial Atherosclerotic Stenosis: The APAC Study
First author：changfeng fan
Corresponding author：xingquan zhao
essential_information
- Person in charge：changfeng fan
- Data Sources： APAC
- Number of papers：APAC20200161
- Published time：2020-04-24
2020-04-24
Published articles
Journal：Journal of Clinical Neuroscience
Publication type: Original Articles
IF(IF): 1.961
PMID: 32340844 Link To Pubmed Full text Download
Background And Purpose
Introduction Asymptomatic intracranial atherosclerotic stenosis (AICAS) is a common cause of stroke. Elderly women were more likely than men to develop AICAS, although it indicated that a lifelong exposure to estrogen could lower the risks of cardiovascular disease (CVDs). Objective The present study aims to ascertain whether postmenopausal time is a risk factor of AICAS. Fostering a correct perception of menopause is of great significance for the overall well-being of the elderly women.
Method
Methods All participants received a questionnaire, physical examination, laboratory testing and transcranial Doppler. The menopausal population (n=701) was divided into three groups by tertiles of postmenopausal time. Two-tailed testing and trend test were used to reveal the relationship between postmenopausal time and newly discovered AICAS. Other potential risk factors were also analyzed to ascertain whether there was a relation between postmenopausal time and the newly discovered ICAS.
Conclusion
Postmenopausal time is not an independent risk factor of AICAS. No relationship was detected between postmenopausal time and newly discovered AICAS, while vigorous control of body weight, blood pressure/glucose/lipids and smoke cessation are vital for preventing the occurrence of AICAS.
Main results
Both mean age and mean postmenopausal time were gradually increased from G0 to G2. The same trend occurred in hypertension, diabetes mellitus, total cholesterol, triglyceride, C-reactive protein and serum homocysteine. Adjusting for various confounding factors, postmenopausal time was not a risk factor for newly discovered AICAS. Multifactor analysis and stratifying analysis showed no correlation between newly discovered AICAS and postmenopausal time.