国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
High lactate dehydrogenase was associated with adverse outcomes in patients with acute ischemic stroke or transient ischemic attack
第一作者：Anxin Wang
通讯作者：Yongjun Wang
基本信息
- 负责人：Anxin Wang
- 数据来源： CNSR-Ⅲ
- 论文编号：CNSR-Ⅲ20200193
- 发表时间：2021-08-30
2021-08-30
已发表文章
发表杂志：Annals of Palliative Medicine
发表类型: Original Article
影响因子(IF): 2.595
PMID: 34498480 Pubmed原文链接 全文下载
主要研究背景及目的
Previous study have found that lactate dehydrogenase (LDH) levels predicted poor outcomes in hemorrhagic stroke, but the prognostic role of LDH in ischemic stroke remains unclear. The study aimed to investigate the association between LDH and adverse outcomes in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA)
方法
All patients were enrolled from the Third China National Stroke Registry (CNSR-III). Adverse outcomes included all-cause death and poor functional outcomes [defined as modified Rankin Scale (mRS) score 3–6 and 2–6] at 3 months and 1 year. Multivariable Cox proportional hazards models and logistic regressions were used to evaluate the association of LDH with risk of all-cause death and poor functional outcomes, respectively.
结论
Higher LDH levels are independently associated with adverse outcomes in patients with AIS or TIA.
主要结果
Among 9,796 included patients, the median [interquartile range (IQR)] of LDH was 175.00 (151.00–205.40) U/L. After adjustment for confounding factors, patients in the highest LDH quartile had a higher risk of all-cause death [hazard ratio (HR), 2.23; 95% confidence interval (CI), 1.27–3.90], and a higher proportion of mRS score 3–6 (odds ratio (OR), 1.54; 95% CI, 1.26–1.90) and mRS score 2–6 (OR, 1.56; 95% CI, 1.32–1.84) at 3 months. We also observed a J-shaped association between LDH and risk of each outcome. Consistent results were found at 1 year.