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High lactate dehydrogenase was associated with adverse outcomes in patients with acute ischemic stroke or transient ischemic attack

First author：Anxin Wang

Corresponding author：Yongjun Wang

: Lactate dehydrogenase (LDH); all-cause death; poor functional outcomes; acute ischemic stroke (AIS); transient ischemic attack (TIA)

essential_information

  • Person in charge：Anxin Wang
  • Data Sources： CNSR-Ⅲ
  • Number of papers：CNSR-Ⅲ20200193
  • Published time：2021-08-30

2021-08-30

Published articles

Journal：Annals of Palliative Medicine

Publication type: Original Article

IF(IF): 2.595

PMID: 34498480 Link To Pubmed Full text Download

Background And Purpose

Previous study have found that lactate dehydrogenase (LDH) levels predicted poor outcomes in hemorrhagic stroke, but the prognostic role of LDH in ischemic stroke remains unclear. The study aimed to investigate the association between LDH and adverse outcomes in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA)

Method

All patients were enrolled from the Third China National Stroke Registry (CNSR-III). Adverse outcomes included all-cause death and poor functional outcomes [defined as modified Rankin Scale (mRS) score 3–6 and 2–6] at 3 months and 1 year. Multivariable Cox proportional hazards models and logistic regressions were used to evaluate the association of LDH with risk of all-cause death and poor functional outcomes, respectively.

Conclusion

Higher LDH levels are independently associated with adverse outcomes in patients with AIS or TIA.

Main results

Among 9,796 included patients, the median [interquartile range (IQR)] of LDH was 175.00 (151.00–205.40) U/L. After adjustment for confounding factors, patients in the highest LDH quartile had a higher risk of all-cause death [hazard ratio (HR), 2.23; 95% confidence interval (CI), 1.27–3.90], and a higher proportion of mRS score 3–6 (odds ratio (OR), 1.54; 95% CI, 1.26–1.90) and mRS score 2–6 (OR, 1.56; 95% CI, 1.32–1.84) at 3 months. We also observed a J-shaped association between LDH and risk of each outcome. Consistent results were found at 1 year.