Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Somatic mutation contributing to clonal haematopoiesis is a risk factor of recurrent stroke in first-ever acute ischaemic stroke: a prospective cohort study
First author：Xin Qiu
Corresponding author：Yongjun Wang,Zixiao Li
essential_information
2022-09-21
Published articles
Journal：Stroke and vascular neurology
Publication type: Original Articles
IF(IF): 9.893
PMID: 36137598 Link To Pubmed Full text Download
Background And Purpose
Clonal hematopoiesis of indeterminate potential (CHIP) is used to describe people who have recurrent mutations in genes related to hematologic malignancies but without a diagnosis of any hematologic malignancy or other clonal disorder. Evidence showed that presence of CHIP was increase with age and it was significantly associated with the risk for coronary heart disease. However, few studies focus on the mechanisms of CHIP in stroke recurrence. Thus, our study aims to assess the incidence of CHIP in patients with stroke and investigate the potential mechanisms of CHIP in stroke recurrence.
Method
We studied a prospective cohort of 6016 patients who had a first-ever AIS in China. Whole-genome sequencing was performed to identify CHIP. High-sensitivity C reactive protein (hs-CRP) levels above 3 mg/L at baseline were defined as hyperinflammation. Recurrent stroke during the 3-month follow-up was the primary outcome.
Conclusion
Our results suggest that somatic mutations contributing to CHIP increase the risk of short-term recurrent stroke in patients who had a first-ever AIS. Hyperinflammation may be important in the relationship between CHIP and recurrent stroke.