国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)- a population-based prospective cohort study: rationale, design and baseline participant characteristics

第一作者：Yuesong Pan ‍‍,Jing Jing, Xueli Cai

通讯作者：Tiemin Wei, Yongjun Wang

Cognitive impairment vascular events cohort study

基本信息

2020-09-09

已发表文章

发表杂志：Stroke Vasc Neurol

发表类型: Study Protocol

影响因子(IF): 4.081

PMID: 32863279 Pubmed原文链接 全文下载

主要研究背景及目的

Cardiovascular diseases and dementia are two major diseases in the elderly. Atherosclerosis is associated with future vascular events and cognitive impairment.

方法

Between May 2017 and September 2019, the PRECISE study enrolled 3067 community-dwelling adults with ages between 50 and 75 years cluster sampled from six villages and four communities of Lishui city in China. Data are collected in face-to-face interviews at baseline, 2-year and 4-year follow-up visits. Brain MRI including high-resolution sequences for intracranial and carotidal arteries and CT angiography for thoracoabdominal arteries were performed at baseline and will be rescanned after 4 years.

结论

The PRECISE study is a population-based prospective cohort study with comprehensive evaluation of atherosclerotic stenosis and plaque using advanced vascular imaging techniques.

主要结果

A total of 3067 subjects were enrolled, among which 53.5% were female with an average age of 61.2±6.7 years. Among them, 2.8%, 8.1%, 43.1% and 21.6% had a history of stroke, coronary heart diseases, hypertension and diabetes mellitus, respectively.