国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association of triglyceride–glucose index with intra- and extracranial arterial stenosis: a combined cross-sectional and longitudinal

第一作者：Anxin Wang,Xue Tian

通讯作者：Shouling Wu,Xingquan Zhao

Triglyceride–glucose index Intracranial artery stenosis Extracranial artery stenosis Cross-sectional analysis

基本信息

2021-08-04

已发表文章

发表杂志：Endocrine

发表类型: Original Article

影响因子(IF): 3.633

PMID: 34347253 Pubmed原文链接 全文下载

主要研究背景及目的

Intracranial arterial stenosis(ICAS) plays an important role in ischemic stroke and transient ischemic attack(TIA). Insulin resistance(IR) is implicated as an important mechanism promoting atherosclerosis. Previous studies has demonstrated that IR is an independent predictor of ICAS and contributes to the onset of ischemic stroke. However, direct measurement methods of IR are hard to perform in clinical practice due to its invasiveness and high price. Recently, the triglyceride-glucose(TyG) index has been proved to be a reliable surrogate marker of IR. Studies has proved TyG index as a marker of the prevalence and progression of cardiovascular disease in the recent years. But few studies focused on the role of TyG index on cerebrovascular diseases like ICAS. Thus, we aim to investigate the relationship between the TyG index and risk of asymptomatic ICAS(AICAS).

方法

Participants were recruited from the Asymptomatic Polyvascular Abnormalities Community study, 5381 participants were enrolled in the cross-sectional analysis, then 3447 and 1853 participants in the longitudinal analysis for incident ICAS and ECAS, respectively. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/ 2]. Multivariable logistic analysis was used to calculate odds ratio (OR) and 95% confidence interval (CI).

结论

Elevated TyG index was significantly associated with a higher risk of ECAS, but not with ICAS in Chinese adults. This conclusion lends support to the clinical significance of the TyG index for the assessment of artery stenosis, especially for ECAS

主要结果

The results of the cross-sectional and longitudinal analysis were basically the same, as the fully adjusted OR comparing participants in the highest tertile versus lowest tertile of the TyG index was 1.34 (95% CI, 1.13–1.59) for the prevalence of ECAS and 1.85 (95% CI, 1.26–2.71) for incident ECAS, respectively. The addition of TyG index to a conventional model had an incremental effect on the predictive value for ECAS. However, we did not observe any significant association between the TyG index and ICAS.