Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：Journal of the Neurological Sciences

Publication type: Article

IF(IF): 4.553

PMID: 35617844 Link To Pubmed Full text Download

血管性认知障碍较为常见，并影响部分卒中人群后续生活质量、生存时间及增加生活负担［1-2］。目前研究开始关注如何通过相关因素分析预测可能导致卒中后认知变化的因素。不同血管供应区及梗死位置在急性卒中后对认知受累情况及认知结局转归可能有所差异，需要进一步明确［3］。明确与认知相关的梗死部位及动脉血供、寻找认知障碍预测指标是卒中后认知障碍预防研究的重要内容。我们希望通过分析急性卒中患者的梗死部位（脑叶、丘脑、基底节、幕下区域等位置）、动脉血供（ACA, MCA, PCA等）与认知变化结局指标变化，探索急性卒中患者梗死部位、动脉血供对卒中后认知变化的影响。

Patients were selected from the Impairment of Cognition and Sleep after AIS or transient ischemic attack in Chinese patients (ICONS) study. Infarct location was assessed by brain magnetic resonance imaging. Cognition was screened at two weeks and 12 months by the Montreal Cognitive Assessment (MoCA). The primary outcome was the cognitive change at 12 months compared to two weeks. We tested the associations with cognitive change using logistic regression analysis.