国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Effects of estimated glomerular filtration rate on clinical outcomes in patients with intracerebral hemorrhage
第一作者：Li zhaoxia
通讯作者：Zhao xingquan
基本信息
- 负责人：Li zhaoxia
- 数据来源： CSCA
- 论文编号：CSCA20210015
- 发表时间：2022-01-08
2022-01-08
已发表文章
主要研究背景及目的
The influence of chronic kidney disease (CKD) on severity and prognosis of spontaneous in intracerebral hemorrhage (ICH) is scarcely investigated . We aimed to explore the association of admission eGFR levels with stroke severity and outcomes in ICH patients.
方法
The patients were divided into four groups according to different eGFR levels(≥90;60-89;45-59;<45).Multivariable logistic regression analysis was used to determine the association of admission eGFR levels with stroke severity, in-hospital complications, discharge deposition, and in-hospital mortality.
结论
Low eGFR at baseline was associated with an increased risk of in-hospital mortality, non-routine discharge, hemorrhagic stroke severity and in-hospital complications such as pneumonia, hydrocephalus and hematoma evacuation in acute ICH patients.
主要结果
A total of 85,167 patients with acute ICH were included in the analysis. Among them, 9493 (11.1%) had a baseline eGFR<60ml/min/1.73 m2. A low eGFR was associated with an increased risk of in-hospital mortality [eGFR 60–89ml/min/1.73 m2, odds ratio (OR) 1.36 (95% confdence interval (CI) 1.21–1.53); eGFR 45–59, 2.35 (1.97–2.82); eGFR<45, 4.18 (3.7–4.72); P for trend <0.0001], non-routine discharge [eGFR 60–89, 1.11 (1.03–1.2); eGFR 45–59, 1.16 (1–1.35); eGFR<45, 1.37 (1.23–1.53); P for trend <0.0001],hemorrhagic stroke severity [eGFR 60–89, 1 (0.95–1.05); eGFR 45–59, 1.39 (1.26–1.53); eGFR<45, 1.81 (1.67–1.96); P for trend <0.0001], in-hospital complications of pneumonia [eGFR 60–89, 1.1 (1.05–1.14); eGFR 45–59, 1.3 (1.2–1.4); eGFR<45, 1.66 (1.57–1.76); P for trend <0.0001] and hydrocephalus [eGFR 60–89, 0.99 (0.87–1.12); eGFR 45–59, 1.37 (1.1–1.7); eGFR<45, 1.54 (1.32–1.8); P for trend =0.0139] after adjusting for confounding factors. With the decline in eGFR, the risk of hematoma evacuation increased in patients with an eGFR 45 to 59ml/min/1.73 m2 (OR 1.48; 95% CI 1.37–1.61). No signifcant association between diferences in eGFR at baseline and in-hospital complication of recurrent intracerebral hemorrhage was observed.