Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

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Association between cumulative exposure to different lipid parameters and risk of newly developed carotid plaque

First author：吴建维

Corresponding author：赵性泉

epidemiology lipid burden carotid plaque risk factors carotid ultrasound

essential_information

  • Person in charge：吴建维
  • Data Sources： APAC
  • Number of papers：KAILUAN STUDY20210022
  • Published time：2021-01-19

2021-01-19

Published articles

Journal：Stroke and vascular neurology

Publication type: Article

IF(IF): 4.081

PMID: 33468640 Link To Pubmed Full text Download

Background And Purpose

Both the magnitude and cumulative exposure of atherogenic lipoproteins have an impact on the atherosclerosis risk, and the exploration focus has shifted from one single lipoprotein assessment to the cumulative exposure of lipoproteins. We aim to investigate the relationship between cumulative exposure to different lipid parameters and the risk of newly developed carotid plaque in this study.

Method

In the Asymptomatic Polyvascular Abnormalities Community study, 2947 participants were included with follow-up every 2 years from 2006 to 2012. Lipid parameters including total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDLC), highdensity lipoprotein cholesterol (HDLC) and non-HDLC were measured. Cumulative exposure was calculated by adding the weighted sum of the difference between the measured value and the cut-off value of each parameter. Newly developed carotid plaques were identified by carotid ultrasound performed at the third and fourth follow-ups.

Conclusion

TC burden, TG burden, LDLC burden and non-HDLC burden are all independent risk factors for newly developed carotid plaque, especially for the vulnerable plaques. Among lipid parameters, non-HDLC burden is an optimal predictor. Moreover, the predictive value remained significant for participants under the age of 65 years old or free of hypertension, diabetes mellitus and hyperlipidaemia.

Main results

In the univariate analysis, non-HDLC burden had the highest ORs among the five lipid parameters for newly developed carotid plaque in each quartile, as 1.0 (reference), 1.35 (1.09–1.67), 1.68 (1.36–2.08) and 2.74 (2.22–3.38) from the lowest to the highest quartile. In the multivariate analysis and sensitivity analysis, we obtained similar results.