国家神经系统疾病临床医学研究中心数据管理与共享系统

发表杂志：Lancet Regional Health-Western Pacific

发表类型: Research Article

影响因子(IF): 8.559

PMID: 35024660 Pubmed原文链接 全文下载

Moyamoya disease (MMD) is a chronic cerebrovascular disease characterized by progressive narrowing of the distal internal carotid arteries and their proximal branches with abnormal collateral vessels,(1) which is a major cause of stroke in children and young adults.(2, 3) MMD has been found to occur in patients with different ethnic backgrounds all over the world, whereas it was more common in East Asian countries, such as Japan, Korea, and China.(4)The national incidence of MMD in Japan and South Korea has been well-documented. In Japan, the annual incidence was 0·35 per 100,000 in 1994, 0·54 per 100,000 in 2003, and 0·94 per 100,000 from 2002 to 2006.(5-7) An upward trend was also observed In Korea, and the annual incidence increased from 1·7 per 100,000 in 2007 to 4·3 per 100,000 in 2013.(8, 9) In the US, although with a much lower prevalence, an increasing trend of hospital admissions was also observed.(10, 11) In Europe, a similar upward trend has also been observed in a Danish population-based study with a relatively low incidence of 0·07 per 100,000.(12) However, the national epidemiological data of MMD in China is still absent, except for studies from Nanjing and Taiwan. The annual incidence was 0·43 per 100,000 persons from 2000 to 2007 in Nanjing based on 15 major hospitals in local areas,(13) and it was 0·15 per 100,000 persons from 2000 to 2011 in Taiwan,(14) which was lower than Japan and Korea. China has 34 provinces, municipalities, and autonomous regions with approximately one-fifteenth of the world’s population. Therefore, clarification of the epidemiology features of MMD in China is of great importance. In this study, we use Hospital Quality Monitoring System (HQMS) maintained by the National Health Commission (NHC) from 2016 to 2018 to firstly report the national epidemiological data of MMD in mainland China.

This report is based on the Hospital Quality Monitoring System, a national database which covers all tertiary hospitals in mainland China. The system consistently collects medical records for all inpatient and include information on department demographic characteristics, diagnoses, procedures, and expenses etc. MMD was identified by ICD-10 code (I67·5).