Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Comparison of VerifyNow, Thromboelastography, and PL-12 in Patients with Minor Ischemic Stroke or Transient Ischemic Attack
First author：Lin Ma,Weiqi Chen
Corresponding author：Yilong Wang
essential_information
- Person in charge：Lin Ma,Weiqi Chen
- Data Sources： PRINCE
- Number of papers：PRINCE20210056
- Published time：2021-03-03
2021-03-03
Published articles
Journal：Aging-US
Publication type: Original Article
IF(IF): 5.682
PMID: 33686963 Link To Pubmed Full text Download
Background And Purpose
High on-treatment platelet reactivity (HOPR) is associated with stroke recurrence. It is important to find a reliable method to assess HOPR. We aimed to compare the correlations between VerifyNowTM system, thromboelastography (TEG), and Aggrestar platelet function analyser (PL-12) on platelet activity in patients with minor ischemic stroke or transient ischemic attack (TIA) after dual antiplatelet therapy for 7 days.
Method
Data was collected from PRINCE study. Peripheral venous blood samples were collected at 2–4 hours after taking the investigational drugs. A value ≥ 550 ARU indicates HOPR-AA and A value > 208 PRU was defined as HOPR-ADP for VerifyNow. We defined a<50% and<30% inhibition of AA- and ADP-induced clot formation as HOPR-AA and HOPR-ADP for TEG, respectively. A value of MARAA ＞ 50% was defined as HOPR-AA, and a value of MARADP ≥ 55% was defined as HOPR-ADP for Pl-12. Spearman’s correlation coefficient and the kappa coefficient were adopted to evaluate associations among the three test methods.
Conclusion
Correlations among different platelet function analysers were varied. VerifyNow and TEG were more correlative than PL-12 on HOPR-ADP. The consistence of HOPR-AA was limited among VerifyNow, TEG and PL-12. The proportion of stroke recurrence and composite events in patients with HOPR-ADP assessing by PL-12 was higher than VerifyNow and TEG.
Main results
The correlations of HOPR-ADP between PL-12 and the other two platelet function analysers were moderate (PL-12 versus VerifyNow, r=0.47, p<0.001; PL-12 versus TEG, r=0.25, p<0.001). The correlations of HOPR-AA were limited among these three platelet function analysers (VerifyNow versus TEG, r=0.09, p=0.14; VerifyNow versus PL-12, r=0.15, p=0.01; PL-12 versus TEG, r=0.10, p=0.09).