国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Comparison of VerifyNow, Thromboelastography, and PL-12 in Patients with Minor Ischemic Stroke or Transient Ischemic Attack

第一作者：Lin Ma,Weiqi Chen

通讯作者：Yilong Wang

High on-treatment platelet reactivity Platelet function Ishemic stroke

基本信息

2021-03-03

已发表文章

发表杂志：Aging-US

发表类型: Original Article

影响因子(IF): 5.682

PMID: 33686963 Pubmed原文链接 全文下载

主要研究背景及目的

High on-treatment platelet reactivity (HOPR) is associated with stroke recurrence. It is important to find a reliable method to assess HOPR. We aimed to compare the correlations between VerifyNowTM system, thromboelastography (TEG), and Aggrestar platelet function analyser (PL-12) on platelet activity in patients with minor ischemic stroke or transient ischemic attack (TIA) after dual antiplatelet therapy for 7 days.

方法

Data was collected from PRINCE study. Peripheral venous blood samples were collected at 2–4 hours after taking the investigational drugs. A value ≥ 550 ARU indicates HOPR-AA and A value > 208 PRU was defined as HOPR-ADP for VerifyNow. We defined a<50% and<30% inhibition of AA- and ADP-induced clot formation as HOPR-AA and HOPR-ADP for TEG, respectively. A value of MARAA ＞ 50% was defined as HOPR-AA, and a value of MARADP ≥ 55% was defined as HOPR-ADP for Pl-12. Spearman’s correlation coefficient and the kappa coefficient were adopted to evaluate associations among the three test methods.

结论

Correlations among different platelet function analysers were varied. VerifyNow and TEG were more correlative than PL-12 on HOPR-ADP. The consistence of HOPR-AA was limited among VerifyNow, TEG and PL-12. The proportion of stroke recurrence and composite events in patients with HOPR-ADP assessing by PL-12 was higher than VerifyNow and TEG.

主要结果

The correlations of HOPR-ADP between PL-12 and the other two platelet function analysers were moderate (PL-12 versus VerifyNow, r=0.47, p<0.001; PL-12 versus TEG, r=0.25, p<0.001). The correlations of HOPR-AA were limited among these three platelet function analysers (VerifyNow versus TEG, r=0.09, p=0.14; VerifyNow versus PL-12, r=0.15, p=0.01; PL-12 versus TEG, r=0.10, p=0.09).