国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Validation of the Canadian TIA Score to Predict Subsequent Stroke Risk in Chinese TIA Patients
第一作者：Chengyuan Yang
通讯作者：Xia Meng,Jie Xu
基本信息
- 负责人：Chengyuan Yang
- 数据来源： CNSR-Ⅲ
- 论文编号：CNSR-Ⅲ20210060
- 发表时间：2022-05-05
2022-05-05
已发表文章
发表杂志：Cerebrovascular disease
发表类型: Original Contributions
影响因子(IF): 3.104
PMID: 35512630 Pubmed原文链接 全文下载
主要研究背景及目的
The recently derived Canadian TIA score performed significantly better predictive effectiveness than the traditional ABCD2 score and was more convenient for clinical application than several variations of ABCD2 score including neuroimaging. However, it still needs external verification of other races to prove the predictive power of Canadian TIA score. Moreover, the Canadian TIA score might have chance to be further simplified and identify specific cut-offs for changes of interventions after TIA onset. Therefore, we aimed to verify and modify the Canadian TIA Score optimised for prevention of subsequent stroke risk after TIA.
方法
The Third China National Stroke Registry (CNSR-III) was a nationwide, multicenter prospective registry recruiting consecutive patients with acute ischemic stroke or TIA within 7 days of the onset from August 2015 to March 2018. The Canadian TIA Score was verified in patients diag- nosed with TIA from the CNSR-III (N = 1,184). The outcomes were subsequent stroke at 7 days, 14 days/discharge, 3 months, and 1 year. Outcomes were recorded by face-to- face assessment or telephone interview. The prognostic per- formance of the scoring system was assessed by the area under the receiver operator characteristic curve (AUC).
结论
The Cana- dian TIA Score might be a better prognostic score than the ABCD2 score for post-TIA stroke risk, especially in patients with atypical TIA.
主要结果
Of 1,184 TIA patients (mean [IQR] age, 61.00 [53.00– 69.00] years; 413 women [34.88%]), there were 40 patients (3.38%) having subsequent stroke within 7 days, 45 (3·80%) within 14 days/hospitalization, 66 (5·57%) within 3 months, and 100 (8·45%) within 1 year. The Canadian TIA Score (AUC 0 63–0·68) seemed to be a better prognostic score of stroke risk than the ABCD2 score (AUC 0·61–0·62), although no sig- nificant differences were noted. In the subgroup of atypical TIA, the Canadian TIA Score showed significantly stronger predictivity than the ABCD2 score within 7 days (0.80 [0.62– 0.98] vs. 0.52 [0.30–0.73]; difference in AUC, 0.28 [0.03–0.53]; p, 0.026), and marginal significantly stronger predictivity within 1 year (0.71 [0.61–0.80] vs. 0.58 [0.48–0.68]; difference in AUC, 0.12 [−0.01 to 0.25]; p, 0.06).