国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association Between the Neutrophil-to-Lymphocyte Ratio and Adverse Clinical Prognosis in Patients with Spontaneous Intracerebral Hemorrhage

第一作者：杜洋

通讯作者：赵性泉,边立衡

neutrophil-to-lymphocyte ratio functional outcome spontaneous intracerebral hemorrhage

基本信息

  • 负责人：杜洋
  • 数据来源：
  • 论文编号：OTHERS20210137
  • 发表时间：2022-05-10

2022-05-10

已发表文章

发表杂志：Neuropsychiatric Disease and Treatment

发表类型: Clinical Study

影响因子(IF): 2.989

PMID: 35586366 Pubmed原文链接 全文下载

主要研究背景及目的

脑出血是脑卒中的第二大类型，具有较高病死率、致残率。脑出血后炎症是脑出血后继发性脑损伤的主要承担者，造成神经细胞的直接炎性损伤及血脑屏障的破坏，进一步加重脑水肿。卒中患者急性期外周血白细胞计数，尤其是中性粒细胞与淋巴细胞比率（NLR）可能反映患者发病时炎症反应程度1, 2，文献报道，缺血性脑卒中、SAH患者NLR与预后有明确相关性3, 4，此外，NLR可能为ICH患者预后的预测指标5。因此，需要需要较大队列对脑出血患者NLR及其预后的相关性进行验证。

方法

All patients were divided into Q1, Q2, Q3 and Q4 groups according to the quartile and median NLR levels. Continuous variables are expressed as medians (interquartile range, IQR) or means ± standard deviation (SD) and were compared by the Kruskal–Wallis test. The chi-square test was used for the comparison of categorical variables, which are expressed as numbers (proportions). Multivariate logistic regression was used to analyze the association between NLR levels and clinical outcomes. Variables with p values < 0.05 from the comparison of baseline characteristics and selected variables (age, sex, smoking, GCS at first admission, NIHSS at first admission, hematoma volume at first admission, systolic blood pressure) were included in multivariate analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each group with the first quartile (Q1) as a reference for the NLR. The results were considered significant for p values < 0.05 (two sided).

结论

A significantly increased NLR may have an impact on the poor outcomes and functional disability of patients with ICH, while a slightly elevated NLR may play a protective role.

主要结果