国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Two-year change in serum total cholesterol is associated with incident ischemic stroke: results from the Kailuan study

第一作者：Yu Wang

通讯作者：Xingquan Zhao,Shouling Wu

total cholesterol risk factor ischemic stroke intracerebral hemorrhage incidence

基本信息

  • 负责人：Yu Wang
  • 数据来源： Kailuan Study
  • 论文编号：KAILUAN STUDY20210150
  • 发表时间：2021-09-29

2021-09-29

已发表文章

发表杂志：Frontiers in Neurology

发表类型: Article

影响因子(IF): 4.003

PMID: 34659084 Pubmed原文链接 全文下载

主要研究背景及目的

Compared with one single measurement, dynamic change of lipid parameter calculated by repeated measurements has been recognized as a potential biometric to make stroke risk assessments. Total cholesterol (TC) is an important risk factor for stroke, but the relationship between TC change and incident stroke has not been investigated thoroughly. We thus aimed to explore the association between 2-year TC change and the risk of incident stroke, both ischemic and hemorrhagic, in the general population.

方法

From June 2006 to October 2007, a total of 70,999 participants with complete TC value at baseline (2006–2007) and the second examination (2008–2009) were included in our study. The change of TC was calculated as the 2-year follow-up TC subtracting baseline TC. Cox proportional hazards regression analysis was used to evaluate the association between the tertile of TC change and risk of incident stroke and stroke subtypes.

结论

Increased 2-year TC change is associated with an elevated risk of incident total stroke and ischemic stroke, irrespective of the baseline TC value. Maintaining a sustained ideal level of TC is important for stroke prevention.

主要结果

A total of 2,815 cases of stroke events were identified with a median follow-up period of 9.0 years. After adjusting for baseline TC and confounding factors, 2-year TC change was independently associated with increased risk of total stroke (HR 1.07, 95% CI 1.02–1.12) and ischemic stroke (HR 1.08, 95% CI 1.03–1.13) per SD (1.04 mmol/L) increase, while no significant association was obtained between TC change and intracerebral hemorrhage (p = 0.659).