Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Risk of arterial stiffness according to metabolically healthy obese phenotype: a combined cross-sectional and longitudinal study in Kailuan cohort
First author：Anxin Wang,Yu Wang
Corresponding author：Shouling Wu,Xingquan Zhao
essential_information
- Person in charge：Anxin Wang,Yu Wang
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20210179
- Published time：2021-06-03
2021-06-03
Published articles
Journal：Aging-us
Publication type: Research Paper
IF(IF): 4.831
PMID: 34081619 Link To Pubmed Full text Download
Background And Purpose
We aim to investigate the risk of incident arterial stiffness according to metabolically healthy obese (MHO) phenotype in Chinese population.
Method
37,180 participants with at least one-time measurement of branchial-ankle pulse wave velocity (baPWV) were included in the cross-sectional analysis, and 16,236 participants with repeated measurement of baPWV during the follow-ups were included in the longitudinal study. Crossclassification of body mass index (BMI) categories and metabolic health status created six groups. Linear and logistic regression analyses were used.
Conclusion
In conclusion, metabolic health status and BMI categories contribute to the progression of arterial stiffness, while BMI is positively associated with arterial stiffness only in metabolically healthy participants.
Main results
The results of cross-sectional and longitudinal investigation were essentially the same, as the abnormality of baPWV increased with BMI categories in metabolically healthy participants, while the increasing tendency disappeared in metabolically unhealthy participants. A 1.4-fold, 2.2-fold increased risk for the new occurrence of arterial stiffness were documented in MHO and metabolically unhealthy obese participants compared to metabolically healthy normal-weight controls in the fully adjusted model. Further stratified analysis showed that metabolic health status was an interaction factor between BMI and arterial stiffness in all study populations (P=0.0001 for cross-sectional study and P=0.0238 for longitudinal study).