Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of Impaired Fasting Glucose With Cardiovascular Disease in the Absence of Risk Factor
First author：Yingting Zuo
Corresponding author：Shouling Wu,Anxin Wang
essential_information
- Person in charge：Yingting Zuo
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20210183
- Published time：2021-11-29
2021-11-29
Published articles
Journal：The Journal of Clinical Endocrinology & Metabolism
Publication type: Research Article
IF(IF): 5.958
PMID: 34748624 Link To Pubmed Full text Download
Background And Purpose
The association between impaired fasting glucose and cardiovascular disease (CVD) in participants without atherosclerotic CVD (ASCVD) risk factors based on current definitions is unclear. The study aimed to examine the association of fasting glucose levels with CVD and its subtypes in persons without ASCVD risk factors.
Method
This study included 38 297 participants [men 62.1%; mean age 47.9 (12.9) years] who were free of a history of CVD and absent of ASCVD risk factors and had a fasting plasma glucose (FPG) level between 70 to 125 mg/dL at baseline from Kailuan Study during 2006 and 2007. Participants were followed until new-onset CVD event, death, or December 31, 2017. Cox proportional hazards models were performed to evaluate the associations.
Conclusion
We found that among individuals without diabetes or other traditional ASCVD risk factors, there is an increased risk of incident CVD with increasing abnormal FPG levels. These results highlight the importance of primordial prevention for FPG level increases along with other traditional ASCVD risk factors.
Main results
During a median follow-up of 11.0 years (interquartile range 10.7-11.2 years), we observed 1217 incident CVD events. Compared with participants with FPG 70 to 99 mg/dL, the multivariable adjusted hazard ratios for CVD among participants with FPG 100 to 109 mg/dL and 110 to 125 mg/dL were 1.18 (95% CI 1.02-1.38) and 1.27 (95% CI 1.03-1.55), respectively. Multivariable-adjusted spline regression model showed a J-shaped association between FPG and the risk of CVD.