国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Effect of changes in serum uric acid on the risk of stroke and its subtypes
基本信息
- 负责人：Anxin Wang,Xue Tian
- 数据来源： Kailuan Study
- 论文编号：KAILUAN STUDY20210188
- 发表时间：2021-09-22
2021-09-22
已发表文章
发表杂志：Nutrition, metabolism, and cardiovascular diseases
发表类型: Original Contributions
影响因子(IF): 4.22
PMID: 34857424 Pubmed原文链接 全文下载
主要研究背景及目的
The role of serum uric acid (SUA) in stroke remains controversial and analyses of changes in SUA and stroke are limited. The objective of the study was to investigate the associations of changes in SUA with stroke and its subtypes (ischemic and hemorrhagic stroke)
方法
A total of 51 441 participants (mean age 52.69-11.71 years) without history of myocardial infarction or stroke were enrolled. Participants were divided into four groups based on SUA level changes during 2006 and 2010: stable low, increasing, decreasing, and stable high. SUA score was quantified on a 3-point scale with 1 point awarded for hyperuricemia at either year 2006, 2008 or 2010. Multivariate Cox proportion models were used to calculated hazard ratios (HRs) and their 95% confidence intervals (CIs)
结论
Stable high SUA was positively associated with the risk of hemorrhagic stroke, but not with total and ischemic stroke risk.
主要结果
During 7.03-year follow up, 1611 stroke (1410 ischemic stroke, 199 hemorrhagic stroke, and 47 subarachnoid hemorrhage) were identified. Participants with stable high SUA had higher risk of hemorrhagic stroke, the HR was 1.93 (95% CI: 1.06e3.51), compared to those with stable low SUA. Furthermore, cumulative high SUA exposure also increased the risk of hemorrhagic stroke, the HR (95%CI) was 2.99 (1.55 e5.74), compared with cumulative low SUA exposure. However, no significant evidence indicated changes in SUA was associated with the risk of total and ischemic stroke, the HRs (95% CIs) were 0.98 (0.74e1.29) and 0.88 (0.65e1.19), respectively.