Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association between Diabetes Duration and 1-Year Prognosis of Stroke: A National Registry Study
First author：Yanli Zhang
Corresponding author：Yongjun Wang; Yuesong Pan
essential_information
- Person in charge：Yanli Zhang
- Data Sources： CNSR-Ⅲ
- Number of papers：CNSR-Ⅲ20210220
- Published time：2022-08-08
2022-08-08
Published articles
Journal：Brain and behavior
Publication type: Original Article
IF(IF): 3.405
PMID: 35941828 Link To Pubmed Full text Download
Background And Purpose
Although diabetes mellitus (DM) is a strong independent risk factor of stroke recurrence, it is unclear about the association between diabetes duration and prognosis of stroke. The aim of this study is to evaluate the association of diabetes duration and the risk of stroke outcomes.
Method
Cox proportional hazard regression model was used to assess the association of diabetes duration with stroke recurrence and all-cause mortality from symptom onset to one year, and the multivariable logistic regression model was used to assess the association of diabetes duration with poor functional outcome.
Conclusion
Long-term diabetes duration (≥8 years), but not short-term diabetes duration, was associated with an increased risk of 1-year stroke recurrence in patients with ischemic stroke or TIA.
Main results
Among the 14,674 patients included, the average age was 62.0 years, and 68.5% were male. There were 1419 (9.7%) patients who had stroke recurrence, 1912 (13.0%) who had poor function outcome, and 478 (3.3%) who had all-cause mortality at the 1-year follow-up. After adjusting for potential covariates, a diabetes duration ≥8 years was associated with an increased risk of 1-year stroke recurrence (adjusted hazards ratio [HR], 1.31; 95% CI, 1.05-1.64; p = .02) in comparison to those without Diabetes mellitus. Using a competing risk regression model, a diabetes duration ≥8 years was a significant risk factor for stroke recurrence (HR, 1.31; 95% CI, 1.12-1.53). In contrast, there was no significant association between diabetes duration < 4, 4 to <8 years and clinical outcomes.