国家神经系统疾病临床医学研究中心数据管理与共享系统

发表杂志：Biomedicines

发表类型: Original Contributions

影响因子(IF): 6.081

PMID: 34944763 Pubmed原文链接 全文下载

Low level of high-density lipoprotein cholesterol (HDL-C) is a well-established risk factor for cardiovascular diseases. Previous studies found a strong inverse association of HDL-C with worse outcomes. Experimental studies have found that the functionality of HDL may be lost in the diabetes mellitus (DM) state. A dose–response association between high HDL-C concentrations and high CVD risk was observed in participants with DM. However, few studies have assessed whether low levels of HDL-C were associated with an increased risk of adverse outcomes among AIS patients with DM.

We described continuous variables as mean±SD or median (interquartile range) and categorical variables as proportions. Baseline characteristics stratified by HDL-C quintiles were compared by χ2 test for categorical variables and Kruskal-Wallis test for continuous variables for difference between the 5 groups. Cox proportional hazards models were used to calculate the hazard ratios (HRs) and 95% CIs. A 2-tailed P of <0.05 was considered as statistical significance. All statistical analyses were carried out by SAS software, version 9.4 (SAS Institute, Inc, Cary, NC).