国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Prognostic value of glycemic gap in patients with spontaneous intracerebral hemorrhage

第一作者：Chuanying Wang

通讯作者：Xingquan Zhao

Glycemic gap Intracerebral hemorrhage Outcome Predictive value

基本信息

  • 负责人：Chuanying Wang
  • 数据来源：
  • 论文编号：脑出血登记20220004
  • 发表时间：2022-06-02

2022-06-02

已发表文章

发表杂志：European journal of neurology

发表类型: Clinical Study

影响因子(IF): 6.288

PMID: 35652741 Pubmed原文链接 全文下载

主要研究背景及目的

Intracerebral hemorrhage (ICH) has a high mortality and morbidity in the world. However, the prediction of severity and prognosis of ICH is still challenging. Previous study has showed that high CRP level is independently associated with poorer clinical outcome and higher in-hospital mortality in patients with ICH. Recently, the CRP/albumin ratio has been established as an independent prognostic marker in patients with severe illness, infection or malignancy. However, the association between C-reactive protein/albumin ratio and the severity and prognosis of intracerebral hemorrhage has not been evaluated.

方法

The current study included 528 patients from a multi-center, prospective, consecutive, observational cohort study. Poor clinical outcome was defined as the modified Rankin Scale ≥ 3. GG was calculated using admission blood glucose minus hemoglobin A1c-derived average blood glucose. Logistic regression analyses were performed to determine the association between GG and poor clinical outcomes at 30-day, 90-day and 1-year.

结论

GG was independently associated with poor outcomes and may be a valuable prognostic factor in patients with sICH.

主要结果