国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
基本信息
- 负责人：Dandan Liu,Xueli Cai
- 数据来源： PRECISE
- 论文编号：PRECISE20220005
- 发表时间：2022-08-17
2022-08-17
已发表文章
主要研究背景及目的
Cerebral small vessel disease (CSVD) refers to a group of pathological processes with various aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. Its pathogenesis and risk factors is unknown. And few studies specifically investigate the association between LS7 and the risk of cerebral small vessel disease. Thus, we aimed to investigate whether LS7 score were associated with the risk of CSVD including total cerebral small vessel disease burden and magnetic resonance imaging (MRI) markers of CSVD.
方法
We used Kruskal-Wallis Test and Pearson’s Chi-Square Test to compare continuous and categorical variables, respectively. We examined the association of the LS7 score with total CSVD burden and MRI markers by the ordinal and binary logistic regression analysis.
结论
Ideal LS7 score, indicating excellent cardiovascular health, was associated with lower total CSVD burden. Optimizing the risk factors captured by LS7 may reduce the progression of CSVD.