国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
the role of hsCRP in recurrent stroke differed between nondisabling and disabling cerebrovascular event
第一作者：JIEJIE LI
通讯作者：YONGJUN WANG
2023-02-20
已发表文章
发表杂志：Journal of clinical medicine
发表类型: Original Contributions
影响因子(IF): 4.96
PMID: 36836211 Pubmed原文链接 全文下载
主要研究背景及目的
Subsequent stroke was common, especially for the patients with minor stroke and transient ischemic attack. Thought the mechanisms that precede impending stroke and other vascular events are relatively unexplored, relationship between hsCRP and recurrent stroke has been studied. However, whether the role of hsCRP in recurrent stroke differed between TIA/minor stroke and disabling stroke was unknown.
方法
Patients were categorized into 2 groups based on NIHSS of 3. The primary outcomes consisted of stroke recurrence and composite vascular events within one year. The associations of hsCRP with outcomes were analyzed in this two groups of patients using Cox proportional hazards models. Patients were further classified according to TOAST subtype to assess the effect of stroke etiology on the association between hsCRP and recurrent vascular event. In the sensitivity analysis, another cut-point of NIHSS of 5 was used.
结论
Elevated levels of hsCRP were associated with an increased risk of recurrent stroke in minor stroke or TIA patients, irrespective of using a National Institutes of Health Stroke Scale (NIHSS) score of ≤3 (the highest quartile vs. the lowest quartile: adjusted hazard ratio, 1.48; 95% CI, 1.12–1.97; p = 0.007) or ≤5 (the highest quartile vs. the lowest quartile: adjusted hazard ratio, 1.45; 95% CI, 1.15–1.84; p = 0.002) to define minor stroke. Such association was more apparent in the large-artery atherosclerosis subtype